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In addition, non-enzymatic reactions which are integral parts of the metabolic networks with essential roles in cellular metabolism, cannot be captured by the enzyme activity-based metabolomics approaches

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After treatment, DTP cells, as an important component of MRD, persist and remain quiescent ( 3 Drug resistance mechanisms of DTP cell 3.1 Non-genetic resistance mechanisms 3.1.1 Epigenetic reprogramming Epigenetic reprogramming is crucial in forming DTP cells, with histone modifications and chromatin remodeling being core factors

Townsend D, Tew K, Tapiero H

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