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Beyond the nucleus, liothyronine exerts non-genomic actions at the plasma membrane integrin v3, triggering MAPK and PI3K pathways that acutely alter myocardial contractility and vascular tone-effects responsible for its faster onset compared with T4

M Krmer: nothing to disclose, KG Haeusler: reports speakers honoraria, consulting fees, lecture honoraria and/or study grants from Abbott, Alexion, Amarin, AstraZeneca, Bayer Healthcare, Biotronik, Boehringer Ingelheim, Boston Scientific, Bristol-Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Medtronic, Novartis, Pfizer, Portola, Premier Research, Sanofi, SUN Pharma, and W.L

Body weight, body composition, and even gut health can also play a role in its absorption and distribution, thereby affecting the effective 5-Amino-1MQ half life

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Bahrampour, S., Jonsson, C