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Abstract Bacterial infections remain a serious global health threat, exacerbated by the widespread use of antibiotics leading to bacterial resistance

For example, TBI is associated with the upregulation of necroptosis pathways, such as receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL) (Liu et al., 2018

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The warning removal, combined with updated clinical guidelines and growing patient demand, triggered a prescribing surge that the supply chain was not built to absorb