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Oxidative stress, disturbed calcium homeostasis, and metabolic stress lead to the accumulation of misfolded proteins, triggering UPRER, while ROS and Ca 2+ signaling from damaged mitochondria exacerbate this burden

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Hutchins PM, Ronsein GE, Monette JS, Pamir N, Wimberger J, He Y, Anantharamaiah GM, Kim DS, Ranchalis JE, Jarvik GP, Vaisar T, Heinecke JW

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The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation

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Glass et al., 2023)

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