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It is worth noting that cellular senescence also plays important beneficial roles in physiological processes such as tissue development, wound healing, and tumor suppression (Suter et al., 2025)

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Clinical Implications Irritable Bowel Syndrome Differently from IBD and celiac disease, IBS is not associated with overt mucosal inflammation, and evidence supporting the potential role of cytokines in these patients has been so far controversial (Figure 2) (219221)