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Progressive deficiency will lead to mental depression, peripheral neuropathy and fatigue
It is marked by growing submucosal fibrosis, which makes it challenging to open the mouth due to burning sensations (Shih et al., 2019)
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The ability to measure oxidized and reduced forms of NADs and glutathiones from the same sample also minimizes effects of separate sample handling

Drug-induced hyperhidrosis resolves when the causative medication is stopped
