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There are actually five distinct melanocortin receptors (MC1R through MC5R), and they're distributed throughout the body, from the skin and immune cells to the brain and adipose tissue

Long-term stress, however, can result in adrenal fatigue, an autonomic nervous system in a state of imbalance, and heart issues
Most other pathologic conditions affecting lipid transport are due primarily to inherited defects, some of which cause hypercholesterolemia and premature atherosclerosis (Table 26-1)