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doi: 10.1002/da.20700

regulation of the airway microbiota (e.g., probiotic supplementation) can improve host metabolic and immune imbalances (128, 129)

We found remarkably upregulated expression of the marker genes of inflammatory indicators ( TNF- , IL-6 , IL-1 , IL-23 , and Nfb1 ), chemokine CCL2 , and toll-like receptor 4 ( TLR4 , an important pathogen recognition receptor that recognizes mainly LPS of Gram-negative bacteria) in S-amlodipine-treated rats compared with control rats (Figure 2(gh))