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doi: 10.1111/j.1524-6175.2007.06052.x

This amplification of opioid analgesia goes along with the suggested role of the dopamine system failure, and the tonically active anti-opioid system (24-27)

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Directly and indirectly through multiple reactions which include enzymatic reactions, glutathione is oxidized to form GSSG, which is then reduced to GSH, its "active form" by yet another enzymatic reaction (3)
