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Post hoc assessments included change in SBP and DBP from week 0 to week 68 for cagrilintide and semaglutide groups versus placebo and by baseline hypertension (yes/no) in each treatment group
In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis
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The bone volume/tissue volume (BV/TV) of the upper and lower end plates of each intervertebral disc were measured
