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The phrase without the involvement of any other agency (although, rarely, complement is included) indicates that neutralization is typically measured in vitro by incubating antibodies, virus particles and target cells together and demonstrating reduced infection

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[DOI] [PubMed] [Google Scholar] 62.Cogen A.L., Yamasaki K., Sanchez K.M., Dorschner R.A., Lai Y., MacLeod D.T., Torpey J.W., Otto M., Nizet V., Kim J.E., et al

In this study, we inactivated GSTA4 in HCT116 human colon cancer cells and investigated the effect of GSTA4 on cancer cell proliferation and chemoresistance

Substituting arginine for glutamate at this position markedly reduces the analogs affinity for the IGFBPs while leaving its ability to engage the type 1 IGF receptor (IGF-1R) largely intact