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Parameters Sample 1 Sample 2 Sample 3 Mean (U/L) 5.60 24.50 52.30 %CV 4.2 4.3 4.4

The Cell: Organelles Reduced amount of CPG III oxidase Oxidase Neisseria leads to hereditary coproporphyria Hereditary coproporphyria An autosomal dominant porphyria that is due to a deficiency of coproporphyrinogen oxidase in the liver, the sixth enzyme in the 8-enzyme biosynthetic pathway of heme

Then, a grid was generated by taking the standard ligand bound to the co-crystallized protein as the center, and the grid coordinates were noted

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These states were captured in the presence of agonist 2S, 4R-4-methyl glutamate (SYM) 26 and antagonist UBP310 27 respectively (Supplementary Fig