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A study pointed out that the lethal dose of andrographolide-2-hydroxypropyl--cyclodextrin is greater than 2000 mg/kg, and it has no adverse effects on animal growth, circulating blood cells, and liver and kidney functions, and has good safety ( It can be seen that the safety of andrographolide and its derivatives is high, and it is speculated that there is basically no obvious hepatotoxicity, and there is a certain degree of nephrotoxicity and reproductive toxicity, but renal toxicity is mostly related to dose and compound structure, and reproductive toxicity needs further research to confirm