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(F) Histone lactylation inhibits RARg expression in macrophages, consequently enhancing IL-6 levels in the TME and endowing macrophages with tumor-promoting functions ( 4.4 Mammalian cell reprogramming Histone lactylation has also emerged as a crucial epigenetic factor in cellular reprogramming, directly linking metabolic shifts to gene expression regulation

Further investigation into the impact of this molecule on ocular diseases may enrich the understanding of exercises protective mechanisms and potentially offer a new therapeutic strategy for neuroprotection of the visual system

NRF2 regulates mitochondrial redox homeostasis by several mechanisms such as detoxification of peroxides, regeneration of GSH, increased synthesis of GSH and NADPH and via the NRF2-Keap 1 response