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ChaC1 and ChaC2 use the -amine of L-glutamyl residues to cleave the amide bond by transamination, releasing it as a cyclic 5-oxo-l-proline and cysteine glycine dipeptide
57 patients with ASD were enrolled and compared to 29 typically developing controls
The results demonstrated that C35, shown in the Figure 5 below, can inhibit the catalytic activities of both TET1 and TET3 with IC50 values of 3.48 M and 2.31 M, respectively
10.1515/jcim-2016-0083 41 KatariaD.ChahalK
