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Targeting IGF-1R preferentially decreases ALDH + and CD44 + /CD24 CSC populations, suggesting that the IGF pathway sustains the CSC niche [96,98]

mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria

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The major pathways that regulate ferroptosis include the xCT-GPX4-GSH, FSP1-CoQ, DHODH-CoQ, and 7-DHC pathways

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