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A negative one often means the substance stays off the list

Melittin inhibits the Toll-like receptors (TLRs) 2,4, CD14, nuclear factor-B essential modulator (NEMO), and Platelet-derived growth factor receptor (PDGFR) signaling pathways

The growth hormone response naturally declines with age, which partially explains why older patients often experience slower surgical recovery

[DOI] [PubMed] [Google Scholar] 452

doi: 10.1007/s00792-009-0233-7