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These disorders are frequently caused by a confluence of behavioral, physiological, environmental, and genetic variables, and their prevalence is increasing as a result of aging populations, poor diet, stress, and sedentary lifestyles (133)

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Cell 149:10601072 Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR (2015) Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death