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10.1038/nrd.2017.116 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.van Deursen JM

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These results also challenge the fact that APAP-cysteine and NAC-APAP are the main end products of NAPQI elimination, and demonstrate the important role of the thiomethyl shunt in the detoxification of this reactive metabolite

Studies have shown that this approach reduces infarction volume by decreasing calcium influx and the activation of related proteases