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This experimental and computational study revealed how sulfated GAG derivatives (sGAG) influence the interplay of vascular endothelial growth factor (VEGF)165 and its heparin-binding domain (HBD) with the signaling receptor VEGFR-2 up to atomic detail

As the most abundant intracellular antioxidant, glutathione plays a central role in cellular redox homeostasis and has been extensively characterised in biochemical, toxicological, and pharmacological research over several decades

In summary, this study increases our understanding of the role of GPx1 in the induction of protective autophagy in PDA cells under extreme glucose starvation and may provide new therapeutic targets or innovative therapies.

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