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Neurochemical Journal (2020) 6

Anatomically speaking, there are differences in the vagus nerve colon innervation range between animal models (such as rats) and humans (the animal model innervates a greater area, while the human situation is controversial), but this difference does not affect the clinical efficacy of VNS

Drug Metab Dispos Biol Fate Chem 46(9):13381350

This benefit differentiation makes the grapefruit seed extract vs grape seed extract selection heavily favor grape seed extract for applications requiring evidence-based health benefits, established safety profiles, and reliable therapeutic outcomes

doi: 10.1007/s11105-014-0699-z 42 WangJ.ZengQ.ZhuJ.LiuG.TangH