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1 Introduction Methotrexate (MTX) is a dihydrofolate reductase inhibitor and chemotherapeutic agent with proven efficiency against cancers and rheumatoid arthritis (Kozminski et al., 2020)

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Additionally, the high expression of PVP01_1322800 among transition related genes underscores its significance in the parasite's adaptation to host immune pressures and drug resistance

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