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Study Limitations A common limitation in most of the models used to study L-Glu neurotoxicity is that the time used to monitor L-Glu neurodegeneration is typically short and included studies lasting hours and days to a few months, whereas in humans, excessive exogenous L-Glu exposure may be prolonged for years, in keeping with the gradual neuronal degradation that typifies NDDs

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Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, et al