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These antibodies are produced by plasma cells in the synovium, where, in addition to these cells, innate immune cells (monocytes, dendritic cells, mast cells) and adaptive immune cells (T helper 1 and T helper 17 lymphocytes [Th1 and Th17, respectively]) are also present, along with B lymphocytes and fibroblast-like synoviocytes (FSL) [17]
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