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Sulforaphane (SF) is the strongest natural inducer of Nrf2 and phase II detoxifying enzymes and it has a potent anticarcinogenic and chemopreventive effect by inducing apoptosis and cell cycle arrest [110]
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This article will review how heme synthesis enzymes are regulated by housekeeping mitochondrial proteins, and how heme synthesis is regulated by the expression of solute carriers that enable the transport of heme intermediates and other nutrients and metabolites
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