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E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2586 - ESOC25-1678 ATYPICAL PRESENTATIONS IN CADASIL: INTRACRANIAL HAEMORRHAGE AS INDEX PRESENTATION Monturayo Wadzani 1 , Mark Maskery 1 , Amna Sajjad 1 , Mohamed Attia 1 , Ayesha Muneer 1 , Kirsty Ward 1 , Syeda Ismail 1 , Simina Cozma 1 , Dwaipayan Sen 1,2 1 Greater Manchester Comprehensive Stroke Centre, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford Royal Hospital, Manchester, United Kingdom, 2 Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom Background and Aims: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) caused by pathogenic mutations in NOTCH 3 gene is a leading cause of monogenic cerebral small vessel disease resulting in ischaemic strokes and vascular dementia

Fibrosis is staged F0 (none) through F4 (cirrhosis), and clinical trials typically enroll patients with F2F3 (moderate to advanced) fibrosis because that is where the therapeutic need and the regulatory bar is highest

If you choose to self-inject you will improve with each injection and soon clearly understand the best practice procedures and why they are in place

and when delivered as an intramuscular injection, bypasses the digestive system for significantly faster and more complete absorption than oral supplements