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Rillaerts, J

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Using machine-learning approaches and differential gene expression analysis, we identified a loss of transcription factor hypoxia induced factor 1 (HIF-1) expression and activity associated with features of a metabolic switch favoring oxidative phosphorylation and glutathione metabolism over glycolysis in monocytes and dendritic cells

For this axis, relevant endpoints include phosphorylation of anabolic signaling intermediates, expression of muscle-regulatory genes, satellite cell activity, and indices of protein accretion or repair

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues