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Furthermore, the Pt(IV) prodrug was reduced to active Pt(II) drug in cells, releasing the apoptosis sensor TPS-DEVD
Specifically, ferroptosis occurs in the pancreatic tissue of T2DM model rats and high glucose-induced INS-1 cells, with increased iron content and expression of ROS and ACSL4, while GPX4 expression is downregulated [86]
Plant Cell 31:189209 Datta R, Chattopadhyay S (2015) Changes in the proteome of pad2-1, a glutathione depleted Arabidopsis mutant, during Pseudomonas syringae infection
In the present study, both PGC-1 and Nrf1 were markedly downregulated in the livers of patients with MASH
