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Further external validation in a larger population is necessary to confirm this finding

Fold changes were visualized with the ggpubr package (Kassambara, 2020)

Moreover, in a randomized, double-blind, placebo-controlled, phase 2 trial to validate the safety and efficacy of ebselen for the prevention of noise-induced hearing loss [84], 83 participants were allocated to receive 200, 400, or 600 mg ebselen or placebo before a calibrated sound challenge (4 h of pre-recorded music delivered by insert earphones)

Kinetic and X-ray crystallographic studies

Although recently emerged cerebrospinal fluid (CSF) -synuclein seed amplification assays have demonstrated high sensitivity and specificity in identifying PD patients 1 , reliable peripheral fluid biomarkers for PD are currently lacking