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Moreover, the complex mixture of intracellular ligands (free amino acids, other small molecules, adventitious binding sites on the surface of macromolecules), that can be assembled into a diversity of coordination sites with limited geometric constraint, provides an ideal mixture which will inevitably buffer according to the Irving-Williams series [201]

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Additional observations suggest that it may influence cardiac electrical stability and thrombotic processes in preclinical studies

doi: 10.1038/nri2378

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