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FASN FASN is the central enzyme in DNL, catalyzing the synthesis of PA, a long-chain SFA, from acetyl-CoA and malonyl-CoA as substrates, with NADPH serving as a continuous electron donor

doi: 10.1186/1999-3110-55-7 52 FujikawaT.IshiharaH.LeachJ

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To this end, we evaluated multiple cellular parameters including loss of cell viability, caspase 3 activation, GSH-conjugate formation, GSH homeostasis, and cellular stress response pathway activation in mock- and GSTP1 -transfected HepG2 cells