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Thermodynamically, two processes can occur once the -GCL is formed: it may form GSH when it combines with glycine, acting as GSH synthetase (GS, EC 6.3.2.3), or it may interact with the -glutamyl cycle transferase to form 5-oxo-L-proline and L-cysteine

[39] employed GCMS spectral analysis to determine the uptake of dihydrokavain, kavain, desmethoxyyangonin, and yangonin into the male Balb/c mouse brain at 5, 15, 30, and 45 min following intraperitoneal administration

However, when antioxidant defenses are overwhelmed by oxidant insults, as happens in several cutaneous conditions, excessive LPO triggers inflammatory cascades, which lead to tissue damage

Chekuri, G

[DOI] [PubMed] [Google Scholar] Issac, A