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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

doi: 10.1016/j.niox.2019.02.001 150 HedlundPAszdiAPfeiferAAlmPHofmannFAhmadMet al

Many nano-carriers have been considered for antioxidant delivery such as liposomes, polymeric nanoparticles, MOFs and carbon nanostructures (Fig

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doi: 10.3136/fstr.24.943