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Thus, the dysbiotic microbiota in IBS disrupts immune homeostasis, shifting the balance from tolerance towards a state of chronic, low-grade mucosal inflammation and immune activation, which directly contributes to symptom generation, particularly visceral pain

YX: Validation, Writing review and editing

10.1074/jbc.R113.544635 J

Pole test and rotarod test Behavioral tests were conducted 10 days following the final MPTP injection

Recently, it has been shown that LAT1 is in charge of AA transport (Napolitano et al., 2015), whilst 4F2hc heavy subunit acts as a molecular chaperone that directs LAT1 to its definitive localization in the cellular membrane (Nakamura et al., 1999)
