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At therapeutic doses (13 g/day), it significantly raises HDL cholesterol (by 1535%) and lowers LDL and triglycerides , reducing cardiovascular risk

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Safety data from trials In a paper summarizing 6 randomized, double-blind, placebo-controlled human trials, AOD 9604 did not significantly affect IGF-1 levels, did not impair glucose tolerance, and no serious adverse events (SAEs) were attributed to AOD 9604

Intranasal delivery is under study for other peptides for CNS effects and may offer noninvasive systemic access