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Another intriguing research avenue explored the synergy between the ammonia-lowering agent L-ornithine-L-aspartate (LOLA) and the vigilance-enhancing effects of caffeine

59:772-783 [PMC free article: PMC5928430] [PubMed: 29487091] 50

They noted that it may be an effective option to treat mild to moderate ED

PMID: 8085668

Oral intake of 2,400 mg/day for two weeks was also found to be safe in a pilot study that included participants with multiple sclerosis (95)