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Based upon our own work, biguanides do not stimulate canonical skn-1 antioxidant defenses such as gst-4 expression, in contrast to the subtle effects seen in the existing literature (Cabreiro et al., 2013

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The result of a study conducted on peripheral mature T and NK cell lymphomas disclosed the occurrence of TP53 mutations, particularly in patients with 72Pro homozygous genotype, associated with poor prognostic features in this subset of lymphoma

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It has been estimated that a typical diet may contain 3 to 6 grams per day, although this amount could vary based on the types and quantities of foods consumed (10)