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FDAs 2023 Category 2 placement cited immunogenicity risk for certain routes of administration, peptide-related impurities, complexities in active pharmaceutical ingredient (API) characterization, and limited safety information for the proposed routes

We find strong conservation across the animal kingdom of ER-localised GPX7, which may reflect its unique role of preventing oxidative damage during protein folding within the ER

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However, the means by which the BAR domain superfamily proteins assemble into micron-scale structures on phagocytic cups has remained unclear