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Figure 1 VNS modulates PD pathology through two synergistic pathways: (1) Peripheral (Gut) Effects: Reshapes gut microbiota composition and metabolites ( LPS, SCFAs), reduces intestinal inflammation and -Syn expression, and inhibits -Syn propagation to the CNS via the VN

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185 Inconsistencies in the outcome of these studies might be attributed to the heterogeneity of the populations studied and/or different conditions of analysis and concentrations of plasma cysteine used