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In 6-hydroxydopamine (6-OHDA)-lesioned rats, DMF reduced dopaminergic neuron loss, preserved striatal dopamine levels, and attenuated astrogliosis and microgliosis, a function that was associated with NRF2 activation [40]
10.1016/j.celrep.2014.04.030 55 LopesU

Transcription 12 , 5571 (2021)

Recent studies have also shown that SAM can act as a therapeutic agent for treating depression, as an antidepressant in Parkinsons disease, and in endogenous and bipolar patients with depression and hypomanic symptoms (, )
