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Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage

One key difference: tirzepatide is a dual GIP/GLP-1 receptor agonist, while semaglutide targets only GLP-1

Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders
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