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In PTC tumors, the BRAF V600 E mutation has been shown to be positively correlated with mTOR pathway activation and upregulation 21
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Expression, regulation, and triglyceride hydrolase activity of adiponutrin family members

Ethic approval Principles of laboratory animal care were followed, and all studies were previously approved by the Institutional Animal Care and Use Committee and were performed in accordance to the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the National Institutes of Health (Library of Congress Control Number 2010940400, revised 2011)