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High-throughput sequencing and dual-luciferase reporter gene analysis show that exercise induces an increase of skeletal muscle exosomes and exosomal miR-484 could enter the brain through blood circulation to inhibit the expression of ACSL4 and thus inhibit ferroptosis of nerve cells

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Lower expression occurs in several tissues, such as the lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon, and heart

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