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The epigenetic action of vitamin C has also been evaluated during the gene reprogramming of human fibroblasts to induced pluripotent cells (IPSCs), where it has been shown that vitamin C substantially improves the efficiency and quality of reprogrammed cells compared to other antioxidants and that both processes depend on the action of Fe 2+ /-KGDDs activated by vitamin C (Chung et al., 2010

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