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Cardiovascular events, diabetes, psychological factors, and obesity are major contributors to ED, making it essential to adopt healthier habits and therapeutic approaches for sustained results

VDAC opening enhances mitochondrial membrane permeability, leading to glutathione (GSH) depletion and ROS accumulation, thereby accelerating ferroptosis [32]

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And blocking autophagy with 3-MA or chloroquine showed a decrease in spontaneous NETs formation

Interestingly, one of the pathways previously mentioned as a potential target as treatment for DPN, the Nrf2 signaling cascade, serves as a major regulator of antioxidant response elements [88]