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B12 injections are clinically indicated for patients with confirmed deficiency or malabsorption conditions, including those with pernicious anaemia, gastrectomy, ileal resection, Crohn's disease, or neurological symptoms related to B12 deficiency

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In addition, it was reported in DRG neurons of wild type mice and TRPA1 knockout mice that activation of TRPV1 by chemotherapeutic agents induced excessive ROS production and mechanical allodynia

The Reframe In this model, CKD stops being just a kidney problem. It becomes a window into the health of the entire body metabolism, mitochondria, immunity, hormones, toxins, and lifestyle all reflected in the kidneys' function