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Simultaneously, the acidic environment activates G protein-coupled receptors (e.g., GPR65) in T cells, suppressing the mTORC1 signaling pathway, which inhibits the expression of T-bet (a key transcription factor for Th1 differentiation) and enhances the activity of GATA3 (a critical transcription factor for Th2 differentiation) 121,122

S.SainiP.et al (2025)

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Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat

[9] The results have suggested that the peptide may potentially improve sleep patterns in animal research models
