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Core cholesterol mass is related to both LDL particle size (the volume of a sphere is a third power of the radius it can take 40-70% more small particles than large LDL particles to traffic a given cholesterol mass) and the number of TG molecules per LDL particle

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Fibrates decrease APOC2 gene expression through peroxisome proliferator-activated receptor (PPAR) 65 , whereas PPAR coactivator 1 (PGC-1) partners with HNF4 to increase hepatic APOC2 mRNA levels under fasting conditions 68
