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Peroxynitrite induced obvious nuclear distribution of NF-B p65 in SGNs and pretreatment with ebselen significantly reduced it, whereas the lack of GPX1 intensified the nuclear fluorescence of NF-B p65 in SGNs of peroxynitrite + gpx1 / group (Figure 8B)

Targeting mitochondria-mediated ICD can release damage-associated molecular patterns (DAMPs) that promote dendritic cell (DC) maturation and T cell activation

Mitochondria-targeted restriction endonucleases Pathogenic mtDNA variations can introduce unique restriction endonuclease cleavage sites

Resistance to radiotherapy in cancer

Glutathione GSH pka - 8.75 SH HO OH pka - 3.59 pka - 2.12 NHE pka 9.65 1