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As pointed out earlier in this review, transgenic animal studies disrupting one or more IGFBPs have not suggested that a marked growth phenotype should be expected in children and no IGFBP mutations causing growth retardation in children had been reported to the best of my knowledge

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Bauer A.Z., Swan S.H., Kriebel D., Liew Z., Taylor H.S., Bornehag C., Andrade A.M., Olsen J., Jensen R.H., Mitchell R.T., et al

Once- or twice-daily application is standard